Melanoma-Targeting Property of Y-90-Labeled Lactam-Cyclized α-Melanocyte-Stimulating Hormone Peptide
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منابع مشابه
Melanoma-targeting Properties of Technetium-labeled Cyclic a-Melanocyte- stimulating Hormone Peptide Analogues
Preliminary reports have demonstrated that technetium (Tc)-labeled cyclic [Cys, D-Phe]a-MSH3–13 (CCMSH) exhibits high tumor uptake and retention values in a murine melanoma mouse model. In this report, the tumor targeting mechanism of Tc-CCMSH was studied and compared with four other radiolabeled a-melanocyte stimulating hormone (a-MSH) peptide analogues: I-(Tyr)-[Nle, D-Phe]a-MSH [I(Tyr)-NDP];...
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It is estimated that melanoma accounted for 76,380 new cases and 10,130 deaths in the United States in 2016. The melanocortin 1 receptor (MC1R) is highly expressed in the vast majority of melanomas, which makes it an attractive target for molecular imaging and radionuclide therapy. Lactam bridge-cyclized α-melanocyte-stimulating hormone (Ac-Nle4-cyclo[Asp5-His-D-Phe7-Arg-Trp-Lys10]-NH2, or Nle-...
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Objective(s): Malignant melanoma is the most lethal type of skin cancers with unfavorable prognosis. Alpha-MSH peptide analogues have a high affinity for melanocortine-1 (MC1) receptors on melanocytes overexpressing in malignant melanoma cells. Pre-clinical studies have shown promising results for radiolabeled MSH imaging in this malignancy. The purpose of this study is to assess the diagnostic...
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Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target over-expressed on the surface of melanoma cells. Alpha-melanocyte stimulating hormone (alpha-MSH) peptide analogues can specifically bind MC1 receptors with nanomolar binding affinities, making alpha-MSH peptide analogues very promising candidates for developing effective melanoma-specific imaging probes. This review highli...
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OBJECTIVE Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance. Desacetyl-α-MSH, the precursor for α-MSH, is present in brain and blood. Desacetyl-α-MSH is considered to be unimportant for regulating energy b...
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ژورنال
عنوان ژورنال: Cancer Biotherapy and Radiopharmaceuticals
سال: 2019
ISSN: 1084-9785,1557-8852
DOI: 10.1089/cbr.2019.3049